| Written by the Pure Vision Method Team
Last Reviewed: May 16, 2019
Glaucoma more prevailed in cities
Yih-Chung Tham, Xiang Li, Tien Y. Wong, Harry A. Quigley, Tin Aung, Ching-Yu Cheng, “Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: A Systematic Review and Meta-Analysis”, Ophthalmology, Volume 121, Issue 11, 2014,
DNA damage due to oxidative stress is significantly higher in glaucoma patients. Especially in the degenerated areas of the eye that cause glaucoma (trabecular meshwork). The same DNA damage is associated with a higher cancer risk. Glaucoma patients have a higher risk to get cancer.
Alberto Izzotti, Sergio C Saccà, Cristina Cartiglia, Silvio De Flora, “Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients”, The American Journal of Medicine, Volume 114, Issue 8, 2003,
Oxidative stress in the trabecular meshwork directly correlates with IOP and visual field damage.
Saccà SC, Pascotto A, Camicione P, Capris P, Izzotti A. Oxidative DNA Damage in the Human Trabecular MeshworkClinical Correlation in Patients With Primary Open-Angle Glaucoma. Arch Ophthalmol.2005;
Low anti-oxidant levels overall and oxidative stress in the body was also found to correlate to increased IOP and visual field damange
Association between systemic oxidative stress and visual field damage in open-angle glaucoma, Masaki Tanito, Sachiko Kaidzu, Yasuyuki Takai & Akihiro Ohira, Scientific Reports, PY;
Research identified a correlation between food intake and decreased risk of glaucoma in participants. (Fruits & vegetables high in Vitamin A, C, & carotenoids)
The Association of Consumption of Fruits/Vegetables With Decreased Risk of Glaucoma Among Older African-American Women in the Study of Osteoporotic Fractures, American Journal of Ophthalmology, Volume 154, Issue 4, 2012,
Oxidation of fatty acids correlate with glaucoma. Vitamin E is important to protect the optic nerve fibers.
Engin KN, Yemişci B, Yiğit U, Ağaçhan A, Coşkun C. Variability of serum oxidative stress biomarkers relative to biochemical data and clinical parameters of glaucoma patients.
A study showed that glaucoma patients have increased levels of uric acid which shows that their kidneys don’t work properly.
The right diet can significantly reduce the risk of blindness.
Moïse MM, Benjamin L-M, Doris TM, Dalida KN, Augustin NO. Role of Mediterranean diet, tropical vegetables rich in antioxidants, and sunlight exposure in blindness, cataract and glaucoma among African type 2 diabetics. International Journal of Ophthalmology.
Higher dietary nitrate and green leafy vegetable intake was associated with a lower POAG risk
Kang JH, Willett WC, Rosner BA, Buys E, Wiggs JL, Pasquale LR. Association of Dietary Nitrate Intake With Primary Open-Angle GlaucomaA Prospective Analysis From the Nurses’ Health Study and Health Professionals Follow-up Study. JAMA Ophthalmol.
Research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG
Yoo, T., Oh, E., & Hong, S. (2014). Is vitamin D status associated with open-angle glaucoma? A cross-sectional study from South Korea. Public Health Nutrition,
In elderly patients, Glaucoma is a significant predictor of Alzheimer.
There is a close link between glaucoma and Alzheimer’s disease.
Andreas U Bayer, Othmar N Keller, Francis Ferrari, Klaus-Peter Maag,
Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer’s disease and Parkinson’s disease, American Journal of Ophthalmology, Volume 133, Issue 1, 2002,
Glaucoma patients even show an increased amount of biomarkers for Alzheimer in the aqueous humor.
Toshihiro Inoue, Takahiro Kawaji, Hidenobu Tanihara; Elevated Levels of Multiple Biomarkers of Alzheimer's Disease in the Aqueous Humor of Eyes With Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(8):5353-5358. doi: 10.1167/iovs.13-12245.
Glaucoma & Alzheimer’s have the same oxidative stress damage.
Trovato Salinaro Angela, Cornelius Carolin, Koverech Guido, Koverech Angela, Scuto Maria, Lodato Francesca, Fronte Vincenzo, Muccilli Vera, Reibaldi Michele, Longo Antonio, Uva Maurizio G., Calabrese Vittorio; Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer’s disease; Frontiers in Pharmacology; 5/2014
The degeneration of the eye and in Alzheimer’s are very similar and overlapping. Especially in the areas of neuroinflammation, and oxidative damage.
Jeremy M. Sivak; The Aging Eye: Common Degenerative Mechanisms Between the Alzheimer's Brain and Retinal Disease. Invest. Ophthalmol. Vis. Sci. 2013;
Vanderbilt University reports that researchers in the Vanderbilt Eye Institute discovered that glaucoma first starts in the brain.First signs of glaucoma found in brain
Distal axonopathy with structural persistence in glaucomatous neurodegeneration; Samuel D. Crish, Rebecca M. Sappington, Denise M. Inman, Philip J. Horner, David J. Calkins; Proceedings of the National Academy of Sciences Mar 2010,
Glaucoma seems to be a systematic health issue, including sleeping problems, blood pressure, headaches, migraine, thyroid issues, and Autonomic nervous system, so breathing, digestion, and your heart functions.
Pache, Mona, and Josef Flammer. “A Sick Eye in a Sick Body? Systemic Findings in Patients with Primary Open-Angle Glaucoma.” Survey of Ophthalmology 51.3 (2006):
Endocannabinoid System regulates Blood Pressure - CBD good for hypertension (high blood pressure):Blood pressure regulation by endocannabinoids and their receptors
Eye Drops target a 20% eye pressure reduction from the Baseline eye pressure value:What is the target pressure?
Joann A. Giaconi, Fei Yu, Katie L. Stone, Kathryn L. Pedula, Kristine E. Ensrud, Jane A. Cauley, Marc C. Hochberg, Anne L. Coleman,
Yuki, K., Murat, D., Kimura, I. et al. Graefes Arch Clin Exp Ophthalmol (2010).
Article Source: Glaucoma, Alzheimer's Disease, and Parkinson's Disease: An 8-Year Population-Based Follow-Up Study Lin IC, Wang YH, Wang TJ, Wang IJ, Shen YD, et al. (2014) Glaucoma, Alzheimer's Disease, and Parkinson's Disease: An 8-Year Population-Based Follow-Up Study. PLOS ONE 9(10): e108938. https://doi.org/10.1371/journal.pone.0108938